State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Taipa , Macau SAR 999078 , China.
ACS Appl Mater Interfaces. 2018 May 2;10(17):14281-14286. doi: 10.1021/acsami.8b03534. Epub 2018 Apr 19.
Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery but also extends the design of smart materials for biomedical applications.
本文构建了一种基于新型还原响应型柱[5]芳烃的单分子层聚合物纳米胶囊用于药物传递。该功能化体系具有良好的生物相容性，能够高效地内化到靶细胞中，并在还原环境（如细胞质）中明显触发包封药物的释放。此外，这种装载抗癌药物的智能载体对肿瘤细胞增殖具有优异的抑制作用，对正常细胞的副作用较低。这项工作不仅展示了用于抗癌药物靶向传递的新型还原响应型单分子层聚合物纳米胶囊的开发，还扩展了用于生物医学应用的智能材料的设计。
