不宁腿综合征患者心率变异性对心脏自主神经功能的评估

Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome.

作者信息

Yıldız Abdülmelik, Yıldız Cennet, Karakurt Ahmet

机构信息

Department of Cardiology, TEKDEN Hospital, İstanbul, Turkey.

出版信息

Turk Kardiyol Dern Ars. 2018 Apr;46(3):191-196. doi: 10.5543/tkda.2018.33896.

DOI:10.5543/tkda.2018.33896

PMID:29664425

Abstract

OBJECTIVE

The aim of the present study was to investigate cardiac autonomic effects in restless leg syndrome (RLS) using heart rate variability (HRV).

METHODS

A total of 35 patients with RLS and 35 healthy individuals were enrolled in the study. The severity of RLS symptoms was assessed using the International Restless Legs Syndrome Study Group rating scale (IRLS). The correlation between the severity of RLS symptoms and HRV parameters measured on an electrocardiogram was analyzed.

RESULTS

There were no statistically significant differences between the 2 groups with respect to age, gender, or body mass index. The mean heart rate was 85±7.1 bpm in the RLS group compared with 79.6±5.5 bpm in the control group (p=0.001). The standard deviation (SD) of all normal to normal (NN) intervals (SDNN), the mean of the deviation of 5-minute NN intervals over the entire recording (SDNN index), and the SD of the average NN intervals calculated over a 5-minute period of the entire recording (SDANN) were significantly lower in the RLS group compared with the control group (p<0.05 for all). There were no statistically significant differences between the 2 groups in the square root of the mean squared differences of successive NN intervals (RMSSD) and the proportion of adjacent RR intervals differing by >50 milliseconds in the 24-hour recording (pNN50) values (p=0.119 and p=0.07, respectively). In patients with RLS, the low frequency (LF) power and LF/high frequency (HF) ratio were significantly higher than those in the control group (2248.6±245.6 vs 712.1±346.3, 10.7±3.7 vs 2.9±1.8; p<0.0001 and p<0.0001, respectively). Compared with the control group, the RLS group had lower values for HF power, but the difference was not statistically significant (p=0.07). The severity of RLS symptoms was negatively correlated with the SDNN, SDANN index, and pNN50 (r=-0.453 and p=0.009, r=-0.340 and p=0.046, r=-0.446 and p=0.007, respectively), and positively correlated with LF power (r=0.681 and p<0.0001).

CONCLUSION

The study data demonstrated that cardiac autonomic impairment is associated with RLS.

摘要

目的

本研究旨在利用心率变异性（HRV）来研究不宁腿综合征（RLS）患者的心脏自主神经功能影响。

方法

本研究共纳入35例RLS患者和35名健康个体。采用国际不宁腿综合征研究组评分量表（IRLS）评估RLS症状的严重程度。分析RLS症状严重程度与心电图测量的HRV参数之间的相关性。

结果

两组在年龄、性别或体重指数方面无统计学显著差异。RLS组的平均心率为85±7.1次/分钟，而对照组为79.6±5.5次/分钟（p = 0.001）。与对照组相比，RLS组中所有正常到正常（NN）间期的标准差（SDNN）、整个记录中5分钟NN间期偏差的平均值（SDNN指数）以及整个记录中5分钟时间段内计算的平均NN间期的标准差（SDANN）均显著降低（所有p<0.05）。两组在连续NN间期均方根差值（RMSSD）以及24小时记录中相邻RR间期相差>50毫秒的比例（pNN50）值方面无统计学显著差异（分别为p = 0.119和p = 0.07）。在RLS患者中，低频（LF）功率和LF/高频（HF）比值显著高于对照组（分别为2248.6±245.6与712.1±346.3，10.7±3.7与2.9±1.8；p<0.0001和p<0.0001）。与对照组相比，RLS组的HF功率值较低，但差异无统计学显著性（p = 0.07）。RLS症状的严重程度与SDNN、SDANN指数和pNN50呈负相关（分别为r = -0.453，p = 0.009；r = -0.340，p = 个0.046；r = -0.446，p = 0.007），与LF功率呈正相关（r = 0.681，p<0.0001）。