Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department; School of Polymer Science and Engineering , Qingdao University of Science and Technology , Qingdao , 266042 , China.
Biomacromolecules. 2018 Jun 11;19(6):2109-2116. doi: 10.1021/acs.biomac.8b00240. Epub 2018 Apr 17.
Stimuli-responsive polymers have received increasing interest for a variety of applications. Here, we report a series of unique charge-determined thermoresponsive polypeptoids synthesized by a combination of ring-opening polymerization and click chemistry. The LCST-type and UCST-type behavior is mainly dominated by the charge state on the side chain. Further, the phase transition temperature highly depends on the degree of polymerization, the side-chain architecture, the pH value, and so on. The obtained polypeptoid solutions exhibit good stability against temperature and salt concentration. To our knowledge, this report presents the first charge-determined LCST/UCST-type polymer from identical homopolymer backbone that displays a wide range of tunable cloudy points in aqueous media. We propose the hydrogen-bonding interaction plays a critical part on the solution behavior. These features make polypeptoids ideal candidates for highly designable stimuli-responsive polymeric materials.
刺激响应性聚合物因其在各种应用中的广泛应用而受到越来越多的关注。在这里，我们报告了一系列通过开环聚合和点击化学相结合合成的独特的电荷确定的热响应性聚肽。LCST 型和 UCST 型行为主要由侧链上的电荷状态决定。此外，相转变温度高度依赖于聚合度、侧链结构、pH 值等。所得聚肽溶液在温度和盐浓度方面表现出良好的稳定性。据我们所知，本报告首次报道了由相同均聚物主链确定的电荷 LCST/UCST 型聚合物，在水介质中表现出广泛可调的云点。我们提出氢键相互作用在溶液行为中起着关键作用。这些特性使聚肽成为高度可设计的刺激响应性聚合物材料的理想候选物。
