Pennetta Francesca, Lagalla Cristina, Borini Andrea
9.baby, Family and Fertility Center, Centre for Reproductive Health, Bologna, Italy.
Curr Opin Obstet Gynecol. 2018 Jun;30(3):185-196. doi: 10.1097/GCO.0000000000000453.
The purpose of the current review is to provide an update on time-lapse morphokinetic assessment related to embryo ploidy status.
The main limitation of the available studies regarding correlation between morphokinetic variables and ploidy is that each embryo is considered as an independent unit whereas recent findings show that embryo kinetics may be affected by patient and ovarian stimulation-related factors, so that clustered data analysis is more appropriate. Moreover, some experimental evidences show how embryos with irregular developmental patterns, often used as deselection criteria, can evolve into usable embryos and give pregnancy.
Time lapse technology has allowed us to obtain a lot of information about human embryo development through the characterization of events that are otherwise not visible using static morphological observations. Many morphokinetic parameters have been tested in relation to a variety of outcomes including implantation potential, blastocyst development and ploidy status. Regarding to this last point, most efforts aim to unravel this relationship with conflicting results in their predictive ability. Furthermore, embryos originating from anomalous behaviour, although with a reduced developmental potential, may result in euploid and transferrable blastocysts.
本综述旨在提供有关与胚胎倍性状态相关的延时形态动力学评估的最新信息。
现有关于形态动力学变量与倍性之间相关性研究的主要局限性在于，每个胚胎都被视为一个独立单元，而最近的研究结果表明，胚胎动力学可能会受到患者和卵巢刺激相关因素的影响，因此聚类数据分析更为合适。此外，一些实验证据表明，那些通常被用作淘汰标准的发育模式不规则的胚胎，如何能够发育成可用胚胎并实现妊娠。
延时技术使我们能够通过表征那些用静态形态学观察无法看到的事件，获取大量有关人类胚胎发育的信息。许多形态动力学参数已针对包括着床潜能、囊胚发育和倍性状态在内的各种结果进行了测试。关于最后这一点，大多数研究致力于揭示这种关系，但其预测能力的结果相互矛盾。此外，源自异常行为的胚胎，尽管发育潜能降低，但可能会产生整倍体且可移植的囊胚。
