Chemistry Division, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC, 20375, USA.
National Cancer Institute/National Institutes of Health, Frederick, MD, 21701, USA.
Macromol Biosci. 2018 May;18(5):e1700414. doi: 10.1002/mabi.201700414. Epub 2018 Apr 17.
A novel hemostatic and absorbent wound dressing material compatible with 3D printing is developed to address deficiencies in current wound dressing protocol. The design involves an open celled, microporous hydrogel foam via a high internal phase emulsion (HIPE) template with biocompatible components and tunable hemostatic character by kaolin loading, the viscosity and cure kinetics of which are tailored for 3D printing applications. The use of nontoxic mineral oil organic phase results in cytocompatability with human dermal fibroblasts. Kaolin distribution is shown by X-ray diffraction and elemental dispersive spectroscopy to be exfoliated and dispersed in the hydrogel dressing. In addition to demonstrating high fluid absorption and noncytotoxicity of relevant cell lines, the high internal phase emulsion polymers (polyHIPEs) also match the hemostatic performance of commercial wound dressing materials. Furthermore, the polyHIPEs display the requisite rheological properties for 3D printing that result in the fabrication of a prototype dressing with hierarchical porosity and a large number of controllable form factors.
一种新型的止血、吸收性伤口敷料材料与 3D 打印兼容，旨在解决当前伤口处理方案的不足。该设计涉及一种通过高内相乳液 (HIPE) 模板形成的开孔、微孔水凝胶泡沫，具有生物相容性成分和可调节的止血特性，通过高岭土负载来实现，其粘度和固化动力学可针对 3D 打印应用进行定制。使用无毒矿物油有机相可确保与人真皮成纤维细胞的细胞相容性。X 射线衍射和元素分散光谱显示，高岭土在水凝胶敷料中呈剥离和分散状态。除了证明相关细胞系具有高流体吸收性和非细胞毒性外，高内相乳液聚合物 (polyHIPEs) 还具有与商业伤口敷料材料相当的止血性能。此外，polyHIPEs 还表现出 3D 打印所需的流变性能，从而制造出具有分级多孔性和大量可控制形状因子的原型敷料。
