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[感染鼠疫的大沙鼠中的抗原尿]

[Antigenuria in plague-infected great gerbils].

作者信息

Punskiĭ E E, Levi M I, Traub L A, Punskiĭ I E, Temiralieva G A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1988 Feb(2):112-8.

PMID:2966529
Abstract

In the urine of plague-infected great gerbils Yersinia pestis capsular antigen was detected by means of diagnostic preparations, both commercial and experimental (based on monoclonal antibodies). The antigen was detected in many urine samples taken from the animals over a prolonged period. The incidence and duration of antigenuria were found to be related to the survival time of great gerbils after infection and the level of antibodies in their blood. The number of animals with antigenuria markedly exceeded the number of animals from which Y. pestis was isolated, especially at a later period after infection. Examinations of urine samples from live great gerbils trapped in natural foci appears to be a method more effective in epizootiological survey than the bacteriological analysis of the animals.

摘要

利用市售的和实验性的(基于单克隆抗体)诊断制剂,在感染鼠疫的大沙鼠尿液中检测到了鼠疫耶尔森菌荚膜抗原。在较长时间内从这些动物采集的许多尿液样本中都检测到了该抗原。发现抗原尿的发生率和持续时间与大沙鼠感染后的存活时间及其血液中的抗体水平有关。出现抗原尿的动物数量明显超过分离出鼠疫耶尔森菌的动物数量,尤其是在感染后的后期。对从自然疫源地捕获的活大沙鼠尿液样本进行检测,似乎是一种在动物流行病学调查中比动物细菌学分析更有效的方法。

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