Phillips G
Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock.
Anesth Analg. 1988 May;67(5):462-5.
The purpose of this study was to determine if the addition of sufentanil would improve the quality of analgesia obtained with 0.125% epidural bupivacaine infusions given to women in active labor. Forty healthy laboring women were randomly assigned to two equal groups. Group 1 had epidural analgesia instituted with the bolus injection of 10-15 ml 0.125% bupivacaine containing sufentanil 2 micrograms/ml, followed 30 minutes later by initiation of an epidural infusion of 0.125% bupivacaine containing sufentanil 1 microgram/ml at a rate of 10 ml/hr. Group 2 had epidural analgesia instituted with 10 or 15 ml of 0.25% bupivacaine with an epidural infusion of 0.125% bupivacaine begun 30 minutes later at a rate of 10 ml/hr. Infusion rates were altered as required to maintain an analgesic level to the tenth thoracic dermatome. Analgesia assessed by visual analog pain scores was significantly better in group 1. Significantly fewer epidural injections were required in group 1, and less motor weakness occurred in these patients. The addition of sufentanil to epidural bupivacaine infusions given in labor improves analgesia and reduces "top-up" requirements.
本研究的目的是确定添加舒芬太尼是否会提高给处于活跃期分娩的女性输注0.125%硬膜外布比卡因时获得的镇痛质量。40名健康的分娩女性被随机分为两组，每组人数相等。第1组通过推注10 - 15毫升含2微克/毫升舒芬太尼的0.125%布比卡因开始硬膜外镇痛，30分钟后以10毫升/小时的速率开始输注含1微克/毫升舒芬太尼的0.125%布比卡因。第2组通过推注10或15毫升0.25%布比卡因开始硬膜外镇痛，30分钟后以10毫升/小时的速率开始输注0.125%布比卡因。根据需要调整输注速率以维持至胸10皮节的镇痛水平。通过视觉模拟疼痛评分评估的镇痛效果在第1组明显更好。第1组所需的硬膜外注射次数明显更少，且这些患者出现的运动无力情况更少。给分娩时的硬膜外布比卡因输注中添加舒芬太尼可改善镇痛效果并减少“追加”需求。
