卡那单抗与肺癌：耐人寻味，但确有其事？
Canakinumab and Lung Cancer: Intriguing, but Is It Real?
机构信息
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.
出版信息
Oncologist. 2018 Jun;23(6):637-638. doi: 10.1634/theoncologist.2018-0116. Epub 2018 Apr 17.
Abstract
The relationship between inflammation and cancer is complicated. This editorial calls attention to intriguing findings of the CANTOS trial, which was designed to test the hypothesis that an anti‐inflammatory intervention could reduce the incidence of heart attacks, stroke, or cardiovascular death in patients with elevated C‐reactive protein.
摘要
炎症与癌症之间的关系很复杂。这篇社论提请人们注意 CANTOS 试验的有趣发现，该试验旨在检验假设，即抗炎干预是否可以降低 C 反应蛋白升高的患者心脏病发作、中风或心血管死亡的发生率。
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本文引用的文献
1
Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.卡那单抗抑制白细胞介素-1β对动脉粥样硬化患者肺癌发病的影响：一项随机、双盲、安慰剂对照试验的探索性结果。
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.
2
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.卡那奴单抗治疗动脉粥样硬化疾病的抗炎疗法。
N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27.
3
Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial.西妥昔单抗治疗多发性 Castleman 病的随机、双盲、安慰剂对照试验。
Lancet Oncol. 2014 Aug;15(9):966-74. doi: 10.1016/S1470-2045(14)70319-5. Epub 2014 Jul 17.
4
Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.硼替佐米-美法仑-泼尼松联合或不联合西妥昔单抗（抗白细胞介素-6）治疗多发性骨髓瘤的2期随机研究。
Blood. 2014 Jun 26;123(26):4136-42. doi: 10.1182/blood-2013-12-546374. Epub 2014 May 15.
5
IL-1 is required for tumor invasiveness and angiogenesis.白细胞介素-1是肿瘤侵袭和血管生成所必需的。
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2645-50. doi: 10.1073/pnas.0437939100. Epub 2003 Feb 21.
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