Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
J Hum Genet. 2018 Jul;63(7):783-794. doi: 10.1038/s10038-018-0450-y. Epub 2018 Apr 18.
Epidemiological studies undertaken over the past decades reveal a gradual but progressive increase in the incidence and mortality attributable to lung cancer in the Islamic Republic of Iran, a sovereign state geographically situated at the crossroads of Central Eurasia and Western Asia. We identified references published in English and Persian through searches of PubMed, EMBASE, Web of Science, Scopus, and the Scientific Information Database (SID)-a specialized Iranian database, which indexes Iranian scientific journals-between inception and 15 September 2017. Of 1475 references identified through electronic searches, we reviewed the full text of 88 studies, and included 38 studies in the review. Potentially druggable NSCLC targets, which have been studied in Iran include EGFR, ALK, ERBB2, and KIT; but no studies were found, which examined the impact of MET, ROS1, BRAF, PIK3CA, and FGFR1 aberrations. We were able to identify some literature on DNA repair genes and xenobiotic metabolism, including TP53, TP63, ERCC2, XRCC2, SIRT1, PTEN, CYP1A1, CYP1B1, GSTT1, and GSTM1. We also found an increasing amount of research performed in relation to the tumor microenvironment and immune contexture, including CTLA4, MAGE, FOXP3, IFN-γ, and various interleukins, chemokines, and transcription factors; but did not identify any publication concerning the expression of PD-1/PD-L1 in lung cancer. Our survey of research performed in Iran has revealed a dearth of studies in topics, which are otherwise highly pursued in developed countries, but nevertheless, has begun to hint at a distinct biology of lung cancer in this part of the world.
过去几十年进行的流行病学研究显示，伊朗伊斯兰共和国肺癌的发病率和死亡率逐渐但持续上升，伊朗是一个主权国家，地理位置位于中亚和西亚的十字路口。我们通过检索 PubMed、EMBASE、Web of Science、Scopus 和专门的伊朗科学信息数据库（SID），查找了以英文和波斯文发表的参考文献，该数据库索引了伊朗的科学期刊。在电子检索中确定了 1475 条参考文献，我们查阅了 88 项研究的全文，并将 38 项研究纳入综述。在伊朗研究过的潜在可用药的 NSCLC 靶点包括 EGFR、ALK、ERBB2 和 KIT；但没有研究考察 MET、ROS1、BRAF、PIK3CA 和 FGFR1 异常的影响。我们能够找到一些关于 DNA 修复基因和外源性代谢的文献，包括 TP53、TP63、ERCC2、XRCC2、SIRT1、PTEN、CYP1A1、CYP1B1、GSTT1 和 GSTM1。我们还发现越来越多的研究与肿瘤微环境和免疫结构有关，包括 CTLA4、MAGE、FOXP3、IFN-γ 和各种白细胞介素、趋化因子和转录因子；但没有发现任何关于 PD-1/PD-L1 在肺癌中表达的出版物。我们对伊朗进行的研究调查显示，在其他发达国家高度关注的课题方面，研究很少，但尽管如此，已经开始暗示世界这一地区的肺癌具有独特的生物学特性。
