Morath I, Hartmann T N, Orian-Rousseau V
Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Germany.
Laboratory for Immunological and Molecular Cancer Research, Third Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.
Int J Biochem Cell Biol. 2016 Dec;81(Pt A):166-173. doi: 10.1016/j.biocel.2016.09.009. Epub 2016 Sep 15.
CD44 is a cell adhesion molecule that plays an important role in tumor progression and metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix components, including hyaluronan (HA) and osteopontin (OPN), and to messenger molecules, such as growth factors present in the tumor microenvironment. HA and OPN are highly abundant in the leukemic stem cell niche and in solid tumors of various cancer types, where they contribute to the maintenance of the stemness of malignant cells. CD44 has consequently been recognized as a cancer stem cell marker in several types of cancers, which has been a topic of much recent research. In this review we have addressed the question of how CD44 might promote cancer cell stemness by interacting with extracellular matrix components, growth factors and cytokines.
CD44是一种细胞黏附分子，在肿瘤进展和转移中起重要作用。CD44在肿瘤发生中的作用归因于它与细胞外基质成分（包括透明质酸（HA）和骨桥蛋白（OPN））以及信使分子（如肿瘤微环境中存在的生长因子）的结合。HA和OPN在白血病干细胞龛以及各种癌症类型的实体瘤中高度丰富，它们在其中有助于维持恶性细胞的干性。因此，CD44在几种癌症类型中已被公认为癌症干细胞标志物，这一直是近期众多研究的主题。在本综述中，我们探讨了CD44如何通过与细胞外基质成分、生长因子和细胞因子相互作用来促进癌细胞干性的问题。
