甲状腺功能与年轻的甲状腺功能正常成年人的棕色脂肪组织体积和 18F-氟脱氧葡萄糖摄取无关。

Thyroid function is not associated with brown adipose tissue volume and 18F-fluorodeoxyglucose uptake in young euthyroid adults.

机构信息

PROFITH "PROmoting FITness and Health through Physical Activity" Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain.

Pennington Biomedical Research Center, Baton Rouge, Louisiano, USA.

出版信息

Eur J Endocrinol. 2021 Jul 1;185(2):209-218. doi: 10.1530/EJE-21-0192.

DOI:10.1530/EJE-21-0192

PMID:34061765

Abstract

PURPOSE

Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i.e. free triiodothyronine, FT3, and free thyroxine, FT4), under thermoneutral (22-23°C) and cold-induced conditions, and BAT volume, 18F-fluorodeoxyglucose (18F-FDG) uptake and mean radiodensity.

METHODS

A total of 106 young healthy, euthyroid adults (34 men/72 women; 22.0 ± 2.1 years old; 24.9 ± 4.6 kg/m2) participated in this cross-sectional study. BAT volume, 18F-FDG uptake and mean radiodensity were assessed after 2 h of personalized (i.e. contemplating each individual's shivering threshold) cold exposure via positron emission tomography/computed tomography (PET/CT) static scanning. TSH and THs levels were determined before (thermoneutral) and 1 h after the cold exposure.

RESULTS

Cold exposure increased circulating FT4 (P = 0.038) and reduced TSH levels (P ≤ 0.001). Conversely, the FT3 serum concentration was not modified by cold exposure (P = 0.435). No associations were found between the TSH and THs thermoneutral (all P > 0.111) or cold-induced levels (all P > 0.067) and BAT volume, 18F-FDG uptake and mean radiodensity. These findings were independent of sex and BMI.

CONCLUSIONS

Thyroid function is modulated by cold exposure, yet it is not associated with BAT volume or glucose metabolism assessed after 2 h of cold exposure in young healthy, euthyroid adults.

摘要

目的

甲状腺激素（THs）是棕色脂肪组织（BAT）分化的重要介质。然而，TH 浓度与人类 BAT 的关系尚不清楚。本研究在体温中性（22-23°C）和冷诱导条件下，检测循环促甲状腺激素（TSH）和 TH 浓度（即游离三碘甲状腺原氨酸、FT3 和游离甲状腺素、FT4）与 BAT 体积、18F-氟脱氧葡萄糖（18F-FDG）摄取和平均放射密度之间的关系。

方法

共有 106 名年轻健康、甲状腺功能正常的成年人（34 名男性/72 名女性；22.0±2.1 岁；24.9±4.6kg/m2）参与了这项横断面研究。在通过正电子发射断层扫描/计算机断层扫描（PET/CT）静态扫描进行个性化（即考虑每个个体的颤抖阈值）冷暴露 2 小时后，评估 BAT 体积、18F-FDG 摄取和平均放射密度。在冷暴露前（体温中性）和冷暴露后 1 小时测定 TSH 和 TH 水平。

结果

冷暴露增加了循环 FT4（P=0.038）并降低了 TSH 水平（P≤0.001）。相反，FT3 血清浓度不受冷暴露影响（P=0.435）。在体温中性（所有 P>0.111）或冷诱导（所有 P>0.067）时，TSH 和 TH 水平与 BAT 体积、18F-FDG 摄取和平均放射密度之间均无相关性。这些发现与性别和 BMI 无关。