Alghamedi Alla, Buduhan Gordon, Tan Lawrence, Srinathan Sadeesh Kumar, Sulman Joanne, Darling Gail, Kidane Biniam
Section of General Surgery, University of Manitoba, Winnipeg, Canada.
Section of Thoracic Surgery, University of Manitoba, Winnipeg, Canada.
Ann Transl Med. 2018 Feb;6(4):84. doi: 10.21037/atm.2017.11.38.
Esophagectomy is the mainstay of curative therapy for esophageal cancer; however, it is associated with significant morbidity and mortality, with subsequent major impact on quality of life. This paper reviews the evaluation of health-related quality of life (HRQOL) in esophageal cancer patients undergoing curative intent therapy, the relationship between postoperative HRQOL and survival as well the potential utility of pre-treatment HRQOL as a prognostic tool. HRQOL assessment is valuable in helping clinicians understand the impact on patients of esophageal cancer and the various treatments thereof. HRQOL is also valuable as an end-point in studies of esophageal cancer and esophageal cancer treatment. Given the morbidity and mortality associated with the various treatments for esophageal cancer, it could be argued that HRQOL is as important an endpoint as survival, if not more so. Patient-reported pre-treatment HRQOL assessment appears to predict survival better than clinician-derived performance status assessment period. HRQOL assessment also appears to be responsive to surgical and non-surgical therapy and thus could potentially be used in trials and in practice to serve that function. Thus, HRQOL assessment could be a potentially important adjunct in shared decision-making and guiding treatment planning as well as monitoring the progress of treatment.
食管切除术是食管癌根治性治疗的主要手段；然而，它会带来显著的发病率和死亡率，进而对生活质量产生重大影响。本文综述了接受根治性治疗的食管癌患者健康相关生活质量（HRQOL）的评估、术后HRQOL与生存之间的关系以及治疗前HRQOL作为一种预后工具的潜在效用。HRQOL评估有助于临床医生了解食管癌及其各种治疗方法对患者的影响，具有重要价值。HRQOL作为食管癌及食管癌治疗研究的终点也很有价值。鉴于食管癌各种治疗方法相关的发病率和死亡率，可以说HRQOL作为一个终点与生存同样重要，甚至更为重要。患者报告的治疗前HRQOL评估似乎比临床医生得出的体能状态评估更能预测生存情况。HRQOL评估似乎也对手术和非手术治疗有反应，因此有可能在试验和实践中用于此功能。因此，HRQOL评估可能是共同决策、指导治疗计划以及监测治疗进展的潜在重要辅助手段。
