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从社区胃肠炎暴发中检测到的人 G8P[14]组 A 轮状病毒的全基因组分析。

Whole genomic analysis of human G8P[14] group A rotavirus detected from community gastroenteritis outbreak.

机构信息

Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Shinjuku-ku, Tokyo, Japan.

Nagano Environmental Conservation Research Institute, Nagano, Japan.

出版信息

J Med Virol. 2018 Aug;90(8):1411-1417. doi: 10.1002/jmv.25194. Epub 2018 May 8.

DOI:10.1002/jmv.25194
PMID:29667207
Abstract

Several suspected cases of zoonotic transmission of group A rotavirus (RVA)-related gastroenteritis were reported previously. In August 2012, G8P[14] RVA was detected in fecal specimens from a community gastroenteritis outbreak occurring during a school trip. In this study, additional analyses were performed and it was found that this strain had the G8-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3 sequence, similar to bovine-like RVA strains. Some contamination by emesis and diarrheic feces was observed near a rest room in the lodging area. Contact history with animals was unknown in members of this school trip, and this case implied that the strain may have acquired the ability for person-to-person transmission.

摘要

此前曾有几例疑似肠致病性 A 组轮状病毒(RVA)相关胃肠炎的动物源性传播病例报告。2012 年 8 月,在一次学校旅行期间发生的社区胃肠炎暴发的粪便标本中检测到 G8P[14] RVA。在本研究中,进行了进一步的分析,发现该毒株具有 G8-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3 序列,类似于牛源样 RVA 株。在住宿区的休息室附近的呕吐物和腹泻粪便中观察到一些污染。这次学校旅行的成员与动物接触的历史是未知的,这表明该菌株可能已经获得了人际传播的能力。

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