Marton Szilvia, Dóró Renáta, Fehér Enikő, Forró Barbara, Ihász Katalin, Varga-Kugler Renáta, Farkas Szilvia L, Bányai Krisztián
Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
Virus Res. 2017 Jan 2;227:96-103. doi: 10.1016/j.virusres.2016.09.012. Epub 2016 Oct 10.
Genotype P[14] rotaviruses in humans are thought to be zoonotic strains originating from bovine or ovine host species. Over the past 30 years only few genotype P[14] strains were identified in Hungary totaling<0.1% of all human rotaviruses whose genotype had been determined. In this study we report the genome sequence and phylogenetic analysis of a human genotype G8P[14] strain, RVA/Human-wt/HUN/182-02/2001/G8P[14]. The whole genome constellation (G8-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3) of this strain was shared with another Hungarian zoonotic G8P[14] strain, RVA/Human-wt/HUN/BP1062/2004/G8P[14], although phylogenetic analyses revealed the two rotaviruses likely had different progenitors. Overall, our findings indicate that human G8P[14] rotavirus detected in Hungary in the past originated from independent zoonotic events. Further studies are needed to assess the public health risk associated with infections by various animal rotavirus strains.
人类中的基因型P[14]轮状病毒被认为是源自牛或羊宿主物种的人畜共患病菌株。在过去30年里，匈牙利仅鉴定出少数基因型P[14]菌株，占所有已确定基因型的人类轮状病毒的比例不到0.1%。在本研究中，我们报告了一株人类基因型G8P[14]菌株RVA/Human-wt/HUN/182-02/2001/G8P[14]的基因组序列和系统发育分析。该菌株的全基因组组合（G8-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3）与另一株匈牙利人畜共患病G8P[14]菌株RVA/Human-wt/HUN/BP1062/2004/G8P[14]相同，尽管系统发育分析表明这两种轮状病毒可能有不同的祖先。总体而言，我们的研究结果表明，过去在匈牙利检测到的人类G8P[14]轮状病毒源自独立的人畜共患病事件。需要进一步研究来评估各种动物轮状病毒株感染所带来的公共卫生风险。
