Cui Le, Yin Jia
a Department of Allergy, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China.
J Asthma. 2019 May;56(5):505-511. doi: 10.1080/02770903.2018.1466316. Epub 2018 Jul 9.
Artemisia and Humulus pollen are the two most important aeroallergens of autumn allergies in North China. Cross-sectional data in 2001 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients with autumn pollinosis in North China.
We used this cross-sectional data to investigate the association of serum specific IgE (sIgE) levels to Humulus and/or Artemisia pollen with the onset of asthma in patients with autumn pollen-induced allergic rhinitis.
1096 patients with autumn pollinosis were face-to-face interviewed and underwent sIgE tests to Artemisia and Humulus. The temporal sequence of allergic rhinitis and asthma was documented. 1013 patients were positive to Artemisia and/or Humulus by sIgE. Multinomial logistic regression and survival analysis were used to examine the potential implication of sIgE levels for the progression of asthma in autumn pollen-induced allergic rhinitis.
Of the 1013 participants with a positive sIgE test to Artemisia and/or Humulus, 563 (55.6%) had a history of allergic rhinitis which preceded or occurred at the same time as asthma. 450 (44.4%) had allergic rhinitis alone. After controlling of sex, age at onset of allergic rhinitis, and parental asthma, the risk of developing asthma increased with the levels of sIgE to both Artemisia and Humulus (p < 0.05). In Kaplan-Meier analysis, IgE classes 5-6 to Humulus or Artemisia increased the risk of asthma development (p < 0.05).
Autumn pollen-induced allergic rhinitis often coexists with seasonal asthma. The incidence of asthma is more pronounced when the sIgE level was higher.
在中国北方，蒿属花粉和葎草花粉是秋季过敏中两种最重要的气传变应原。2001年的横断面数据显示，在中国北方秋季花粉症患者中，过敏性鼻炎常常先于哮喘出现或与哮喘同时发生。
我们利用这些横断面数据，研究秋季花粉诱导的过敏性鼻炎患者血清中针对葎草和/或蒿属花粉的特异性IgE（sIgE）水平与哮喘发病之间的关联。
对1096例秋季花粉症患者进行面对面访谈，并对其进行针对蒿属和葎草的sIgE检测。记录过敏性鼻炎和哮喘的时间顺序。1013例患者sIgE检测对蒿属和/或葎草呈阳性。采用多项逻辑回归和生存分析，研究sIgE水平对秋季花粉诱导的过敏性鼻炎患者哮喘进展的潜在影响。
在1013例蒿属和/或葎草sIgE检测呈阳性的参与者中，563例（55.6%）有过敏性鼻炎病史，且先于哮喘出现或与哮喘同时发生。450例（44.4%）仅有过敏性鼻炎。在控制性别、过敏性鼻炎发病年龄和父母哮喘因素后，对蒿属和葎草的sIgE水平越高，发生哮喘的风险越高（p<0.05）。在Kaplan-Meier分析中，针对葎草或蒿属的IgE 5-6类增加了哮喘发生的风险（p<0.05）。
秋季花粉诱导的过敏性鼻炎常与季节性哮喘共存。sIgE水平越高，哮喘的发病率越明显。
