Wang Min, Xing Zhimin, Feng Wei, He Xuetao, Ma Youxiang
Department of Otorhinolaryngology, People's Hospital, Peking University, Beijing, 100044, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(20):925-7.
The aim of our study was to clarify the diagnosis value of total IgE and the relationship between total and specific IgE.
Eight-seven Artemisia pollen-sensitive allergic rhinitis patients with obvious autumn onset and 80 nonatopic healthy controls were recruited for this study. Serum levels of total IgE were determined by using the Elecsys IgE reagent kit (Roche). Serum-specific IgE antibodies against Artemisia pollen were measured by using a fluorescent enzyme immunoassay (UniCAP system, Pharmacia and Upjohn Diagnostics).
The serum total IgE levels in patients with allergic rhinitis were compared with the controls. The total IgE levels of the patients were much higher than those of the controls(Geometric mean of the patients and the controls were 0. 185 U/L and 0. 050 U/L respectively, P <0.01). The correlation of the serum Artemisia pollen specific IgE and total IgE levels in patients with allergic rhinitis was made. No correlation was found between the total and specific IgE levels ( P >0. 05).
There are some reference values for the serum total IgE levels to the diagnosis of the Artemisia pollen-induced allergic rhinitis patients. There are no correlation between the serum Artemisia pollen specific IgE and total IgE levels in patients with allergic rhinitis. Its value is limited to predict the specific value according the total IgE.
本研究旨在阐明总IgE的诊断价值以及总IgE与特异性IgE之间的关系。
招募了87例秋季发病明显的蒿属花粉敏感型变应性鼻炎患者和80例非特应性健康对照者进行本研究。采用罗氏Elecsys IgE试剂测定血清总IgE水平。采用荧光酶免疫分析法（Pharmacia和Upjohn诊断公司的UniCAP系统）检测血清中针对蒿属花粉的特异性IgE抗体。
比较变应性鼻炎患者与对照者的血清总IgE水平。患者的总IgE水平远高于对照者（患者和对照者的几何平均值分别为0.185 U/L和0.050 U/L，P<0.01）。对变应性鼻炎患者血清蒿属花粉特异性IgE水平与总IgE水平进行相关性分析。总IgE水平与特异性IgE水平之间未发现相关性（P>0.05）。
血清总IgE水平对蒿属花粉诱发的变应性鼻炎患者的诊断有一定参考价值。变应性鼻炎患者血清蒿属花粉特异性IgE水平与总IgE水平之间无相关性。根据总IgE预测特异性IgE的价值有限。
