接触汽油烟雾对汽油泵工作人员的遗传毒性影响。
Genotoxic Effects of Exposure to Gasoline Fumes on Petrol Pump Workers.
作者信息
Shaikh Amrin, Barot Darshana, Chandel Divya
机构信息
Department of Zoology, BMT and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
出版信息
Int J Occup Environ Med. 2018 Apr;9(2):79-87. doi: 10.15171/ijoem.2018.1159.
BACKGROUND
Petrol pump workers are occupationally exposed to gasoline and its fumes consisting of several mutagenic chemicals.
OBJECTIVE
To evaluate the genotoxic effects of exposure to gasoline fumes on petrol pump workers.
METHODS
The study groups included 70 petrol pump workers (exposed group) and 70 healthy age-matched individuals with no known exposure (comparison group). Buccal micronucleus cytome assay (BMCyt) was performed to check the genotoxicity caused due to inhalation of gasoline fumes.
RESULTS
The frequencies of micronucleated cells, nuclear bud, condensed chromatin cells, karyorrhectic cells, pyknotic cells, and karyolytic cells were significantly higher in the exposed workers compared to the comparison group.
CONCLUSION
Exposure to gasoline fumes is associated with increased frequency of cell abnormalities. This may lead to various health consequences including cancer in those occupationally exposed to gasoline fumes.
背景
加油站工作人员职业性接触汽油及其烟雾，其中含有多种致突变化学物质。
目的
评估接触汽油烟雾对加油站工作人员的遗传毒性作用。
方法
研究组包括70名加油站工作人员（暴露组）和70名年龄匹配、无已知暴露史的健康个体（对照组）。采用颊黏膜微核细胞分析法（BMCyt）检测吸入汽油烟雾所致的遗传毒性。
结果
与对照组相比，暴露组工作人员的微核细胞、核芽、染色质浓缩细胞、核溶解细胞、固缩细胞和核溶解细胞的频率显著更高。
结论
接触汽油烟雾与细胞异常频率增加有关。这可能导致各种健康后果，包括职业性接触汽油烟雾者患癌症。
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