Stratev Velin, Petkova Diana, Dimitrova Valentina, Petev Jordan
Department of Pulmonary Diseases, Prof. Dr. Paraskev Stoyanov Medical University, Varna, Bulgaria.
Clinic of Pulmonary Diseases, St. Marina University Hospital, Varna, Bulgaria.
Folia Med (Plovdiv). 2018 Mar 1;60(1):102-109. doi: 10.1515/folmed-2017-0078.
wis a disease with constantly rising economic and social burden; it is associated with multiple comorbidities which contribute to the disease severity.
To investigate the prevalence of co-morbidities in COPD patients and their association with the disease severity and CRP levels.
We conducted a retrospective study among 338 COPD patients (mean age 65.2±7.6 years) with assessment of comorbidities, spirometry measurements and serum levels of CRP. In 183 patients we found metabolic syndrome (MS) according to IDF criteria.
We found prevalence of cardiovascular diseases (CVD) of 73.5% (hyper-tension 70.4%, CHF 47.4%, ishemic heart disease 37.5%, and cardiac arrhythmias 12.6%), with higher prevalence in patients with more severe disease. We found prevalence of type 2 diabetes of 21.1%, and 12.4% prevalence of bronchiectasis. In a subpopulation of the patients we found 48.1% prevalence of MS and the serum levels of CRP were significantly higher in patients with COPD and MS compared to those without the syndrome: 7.4 (3.14 - 11. 54) mg/ml vs 4.06 (2.64 - 6.93) mg/ml, p=0.006.
The present study suggests high prevalence of CVD comorbidities in COPD patients and association with the disease severity. Metabolic syndrome is a common comorbidity and is associated with increased inflammatory response.
慢性阻塞性肺疾病（COPD）是一种经济和社会负担不断加重的疾病；它与多种合并症相关，这些合并症会加重疾病的严重程度。
调查慢性阻塞性肺疾病（COPD）患者合并症的患病率及其与疾病严重程度和C反应蛋白（CRP）水平的关系。
我们对338例慢性阻塞性肺疾病（COPD）患者（平均年龄65.2±7.6岁）进行了一项回顾性研究，评估了合并症、肺功能测定和血清CRP水平。根据国际糖尿病联盟（IDF）标准，在183例患者中发现了代谢综合征（MS）。
我们发现心血管疾病（CVD）的患病率为73.5%（高血压70.4%，心力衰竭47.4%，缺血性心脏病37.5%，心律失常12.6%），疾病越严重的患者患病率越高。我们发现2型糖尿病的患病率为21.1%，支气管扩张的患病率为12.4%。在患者亚组中，我们发现代谢综合征（MS）的患病率为48.1%，与无该综合征的慢性阻塞性肺疾病（COPD）患者相比，合并代谢综合征（MS）的慢性阻塞性肺疾病（COPD）患者血清CRP水平显著更高：7.4（3.14 - 11.54）mg/ml对4.06（2.64 - 6.93）mg/ml，p = 0.006。
本研究表明慢性阻塞性肺疾病（COPD）患者心血管疾病合并症的患病率较高，且与疾病严重程度相关。代谢综合征是一种常见的合并症，与炎症反应增加有关。
