Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University, Munich, Germany.
Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University, Munich,
J Innate Immun. 2018;10(5-6):479-486. doi: 10.1159/000488091. Epub 2018 Apr 18.
Atherosclerosis is a chronic inflammation of the arterial vessel wall that arises from an imbalanced lipid metabolism. A growing body of literature describes leukocyte recruitment as a critical step in the initiation and progression of lesion development. By contrast, the role of leukocytes during plaque regression has been described in less detail. Leukocyte egress might be an important step to resolving chronic inflammation and therefore it may be a promising target for limiting advanced lesion development. This review aims to summarize our current knowledge of leukocyte recruitment to the arterial vessel wall. We will discuss mechanisms of leukocyte egress from the lesion site, as well as potential therapeutic strategies to promote atherosclerotic regression.
动脉粥样硬化是一种动脉血管壁的慢性炎症，源于脂质代谢失衡。越来越多的文献描述了白细胞募集是病变发展起始和进展的关键步骤。相比之下，白细胞在斑块消退过程中的作用描述得较少。白细胞迁出可能是解决慢性炎症的重要步骤，因此它可能是限制晚期病变发展的一个有前途的靶点。这篇综述旨在总结我们目前对白细胞向动脉血管壁募集的认识。我们将讨论白细胞从病变部位迁出的机制，以及促进动脉粥样硬化消退的潜在治疗策略。
