Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea.
Eur J Clin Nutr. 2018 Dec;72(12):1700-1708. doi: 10.1038/s41430-018-0157-3. Epub 2018 Apr 18.
BACKGROUND/OBJECTIVES: Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or parent-offspring studies. However, data on relative contribution of environmental factors on familial clustering of 25(OH)D in extended families are limited.
SUBJECTS/METHODS: We performed cross-sectional study using data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2012. Familial correlations of 25(OH)D were estimated in 28,551 subjects from 10,882 families. The variance component method was used to assess the relative contribution of additive genetic or environmental contributions to the variation in 25(OH)D level. Logistic regression models with interaction term were built to evaluate the differential influence of parental vitamin D status on the adolescents and adults offspring.
Mean serum 25(OH)D concentration of subjects was 44.6 nmol/L (vitamin D insufficiency (30-50 nmol/L), 51%; vitamin D deficiency ( < 30 nmol/L), 17%). Familial clustering explained 40% of the total variation in 25(OH)D. In the variance component model, 4%, 39%, and 57% of the variation in serum 25(OH)D level was attributed to additive genetic, common shared environmental, and individual environmental factors, respectively. The odds of vitamin D deficiency in offspring with both parents with vitamin D deficiency compared with those with both parents with sufficient vitamin D levels was greater in adolescents ( < 19 years) than in adults ( ≥ 19 years) (odds ratio = 41.1 vs. 12.5; p for interaction = 0.03).
We found a familial clustering of vitamin D deficiency in a large family-based cohort. Parental influence on vitamin D status of offspring was greater in adolescents than in adults.
背景/目的：在双胞胎或亲子研究中报道了血清 25-羟维生素 D 浓度（25（OH）D）的家族相关性。然而，关于环境因素对扩展家族中 25（OH）D 家族聚集的相对贡献的数据有限。
受试者/方法：我们使用 2008-2012 年韩国国家健康和营养检查调查（KNHANES）的数据进行了横断面研究。在 10882 个家庭的 28551 名受试者中，估计了 25（OH）D 的家族相关性。方差成分法用于评估加性遗传或环境因素对 25（OH）D 水平变化的相对贡献。建立了具有交互项的逻辑回归模型，以评估父母维生素 D 状况对青少年和成年子女的不同影响。
受试者的平均血清 25（OH）D 浓度为 44.6nmol/L（维生素 D 不足（30-50nmol/L），51%；维生素 D 缺乏（ < 30nmol/L），17%）。家族聚集解释了 25（OH）D 总变异的 40%。在方差成分模型中，血清 25（OH）D 水平的变异分别归因于加性遗传、共同共享环境和个体环境因素的 4%、39%和 57%。与父母双方维生素 D 水平充足的子女相比，父母双方均为维生素 D 缺乏的子女维生素 D 缺乏的可能性在青少年（ < 19 岁）中大于成年人（ ≥ 19 岁）（比值比=41.1 比 12.5；交互作用的 p 值=0.03）。
我们在一个大型基于家庭的队列中发现了维生素 D 缺乏的家族聚集。父母对子女维生素 D 状况的影响在青少年中大于成年人。
