Couser W G, Abrass C K
Department of Medicine, University of Washington, Seattle.
Annu Rev Med. 1988;39:517-30. doi: 10.1146/annurev.me.39.020188.002505.
Membraneous nephropathy is the most common cause of idiopathic nephrotic syndrome in adults. Recent studies of the pathogenesis of the subepithelial glomerular immune deposits that characterize this disease have revealed new mechanisms of glomerular immune deposit formation involving cell surface antigens and have documented the role of the C5b-9 membrane attack complex of complement in mediating renal injury. Understanding these mechanisms may help us understand the pathogenesis of several other immune-mediated diseases and has implications for possible therapeutic interventions in MN.
膜性肾病是成人特发性肾病综合征最常见的病因。最近对这种疾病所特有的上皮下肾小球免疫沉积物发病机制的研究揭示了涉及细胞表面抗原的肾小球免疫沉积物形成的新机制，并记录了补体C5b - 9膜攻击复合物在介导肾损伤中的作用。了解这些机制可能有助于我们理解其他几种免疫介导疾病的发病机制，并对膜性肾病可能的治疗干预具有启示意义。
