利用婴儿痉挛症的动物模型。
Utilizing Animal Models of Infantile Spasms.
作者信息
Dulla Chris G
机构信息
Department of Neuroscience, Tufts University School of Medicine, Boston, MA.
出版信息
Epilepsy Curr. 2018 Mar-Apr;18(2):107-112. doi: 10.5698/1535-7597.18.2.107.
Abstract
Infantile spasms are a devastating epileptic encephalopathy characterized by early life spasms and later seizures. Clinical outcomes of infantile spasms are poor and therapeutic options are limited with significant adverse effects. Therefore, new strategies to treat infantile spasms are of the utmost importance. Animals models of infantile spasms are a critical component of developing new therapies. Here, we review current chronic animal models of infantile spasms and consider future advances that may help improve patient care, as well as our scientific understanding of this debilitating disease.
摘要
婴儿痉挛症是一种严重的癫痫性脑病，其特征为生命早期出现痉挛，后期出现癫痫发作。婴儿痉挛症的临床预后较差，治疗选择有限且存在显著不良反应。因此，治疗婴儿痉挛症的新策略至关重要。婴儿痉挛症的动物模型是开发新疗法的关键组成部分。在此，我们综述当前婴儿痉挛症的慢性动物模型，并探讨可能有助于改善患者护理以及增进我们对这种致残性疾病科学认识的未来进展。
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