Wilson T A, Dolan L M, McCaughran J A, Dobrozsi D J, Juno C J, Young C A
Department of Pediatrics, SUNY, Stony Brook 11974-8111.
Am J Hypertens. 1988 Jan;1(1):61-3. doi: 10.1093/ajh/1.1.61.
In order to determine the developmental pattern of atrial concentrations of atrial natriuretic factor (ANF) in the Dahl hypertension-prone rat, atrial ANF concentrations were measured in inbred hypertension-prone (S/JR) and hypertension-resistant (R/JR) Dahl rats at 5, 15, 25, and 51 days of age. In both strains, atrial ANF concentrations peaked at 15 days of age. Atrial ANF concentrations did not differ between the two strains from 5 to 25 days of age. However, by 51 days of age, atrial ANF concentrations in the S/JR rat were significantly greater than those of the R/JR rat. Combining these data with developmental patterns of plasma renin activity in S/JR rats suggests the possibility that the S/JR rat may become intravascularly volume-expanded between 25 and 51 days of age. This volume expansion may contribute to the etiology of hypertension in this model of essential hypertension.
为了确定易患高血压的 Dahl 大鼠心房利钠因子（ANF）浓度的发育模式，在 5、15、25 和 51 日龄的近交易患高血压（S/JR）和抗高血压（R/JR）Dahl 大鼠中测量了心房 ANF 浓度。在两个品系中，心房 ANF 浓度在 15 日龄时达到峰值。在 5 至 25 日龄期间，两个品系之间的心房 ANF 浓度没有差异。然而，到 51 日龄时，S/JR 大鼠的心房 ANF 浓度显著高于 R/JR 大鼠。将这些数据与 S/JR 大鼠血浆肾素活性的发育模式相结合，提示 S/JR 大鼠在 25 至 51 日龄之间可能出现血管内容量扩张。这种容量扩张可能有助于这种原发性高血压模型中高血压的病因学。
