Department of Sense Organs, University Sapienza, Rome, Italy.
J Immunol Res. 2018 Feb 18;2018:1454616. doi: 10.1155/2018/1454616. eCollection 2018.
To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO).
Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry. The SDOCT images of the choroid were obtained by EDI modality.
Choroidal thickness was significantly increased in GO than in control eyes ( < 0.01). A significant correlation was found between choroidal thickness and CAS, proptosis, and the duration of disease ( < 0.05).
This study shows that choroidal thickness, evaluated with EDI-OCT, is significantly increased in patients with GO and correlates with the activity of the disease, proptosis, and duration of the disease. The choroidal thickening may reflect the ocular hemodynamic changes, and enhanced depth imaging optical coherence tomography may be a useful tool for the evaluation of orbital congestion and management of patients with Graves' disease and orbital involvement.
探讨应用谱域光相干断层扫描（SD-OCT）和增强深度成像（EDI）技术评估脉络膜厚度在 Graves 病和眼病（GO）患者管理中的作用。
本回顾性观察研究纳入了 18 例 GO 患者的 36 只眼和 18 名年龄匹配的对照者的 36 只眼。所有受试者均接受全面眼科评估，包括临床活动评分（CAS）和眼球突出度测量。通过 EDI 模式获得脉络膜的 SDOCT 图像。
GO 组的脉络膜厚度明显高于对照组（<0.01）。脉络膜厚度与 CAS、眼球突出度和疾病持续时间之间存在显著相关性（<0.05）。
本研究表明，GO 患者的 EDI-OCT 评估的脉络膜厚度显著增加，并与疾病的活动度、眼球突出度和疾病持续时间相关。脉络膜增厚可能反映了眼内血液动力学变化，增强深度成像光相干断层扫描可能是评估眼眶充血和 Graves 病及眼眶受累患者管理的有用工具。
