Kowalik-Jagodzińska Małgorzata, Sobol Maria, Turno-Kręcicka Anna
Department of Ophthalmology, Wroclaw Medical University, 50-367 Wrocław, Poland.
Department of Biophysics Physiology and Pathophysiology, Medical University of Warsaw, 02-004 Warszawa, Poland.
J Clin Med. 2023 Jul 17;12(14):4720. doi: 10.3390/jcm12144720.
This study aims to systematise subfoveal choroidal thickness (SFCT) measured using optical coherence tomography (OCT) in patients with different severities of thyroid eye disease (TED) compared with healthy subjects. The PubMed, Web of Science and Scopus databases were searched for the following terms: ((Graves' ophthalmopathy) OR (thyroid eye disease) OR (Graves' orbitopathy) OR (thyroid-associated orbitopathy)) AND (choroidal thickness) AND ((optical coherence tomography) OR (OCT)). The pool of papers was narrowed down to articles published until 31 January 2023 (26, 26 and 96 papers, respectively). Twenty-five (25) articles were taken into consideration, which were original papers and included the choroidal thickness measurements among TED patients in their results. Finally, eight papers were included in the comparative analysis of the SFCT parameter in TED patients and a group of healthy controls, and seven papers in the comparative analysis of the same parameter between active and inactive TED patients. The mean value of the difference between the TED group and the healthy group was 38.79 μm, with a confidence interval (CI) from 0.09 to 77.49 μm ( = 0.0495). The mean difference between the active TED group and inactive TED group was 38.02 μm, with a CI from 8.62 to 67.42 μm ( = 0.0113). All the results were statistically significant.
本研究旨在对甲状腺眼病（TED）不同严重程度患者使用光学相干断层扫描（OCT）测量的黄斑中心凹下脉络膜厚度（SFCT）进行系统化，并与健康受试者进行比较。在PubMed、Web of Science和Scopus数据库中搜索了以下术语：（（格雷夫斯眼病）或（甲状腺眼病）或（格雷夫斯眶病）或（甲状腺相关眶病））与（脉络膜厚度）以及（（光学相干断层扫描）或（OCT））。论文库被缩小到截至2023年1月31日发表的文章（分别为26篇、26篇和96篇）。考虑了25篇文章，这些文章均为原创论文，其结果中包括了TED患者的脉络膜厚度测量。最后，8篇论文纳入了TED患者与健康对照组SFCT参数的比较分析，7篇论文纳入了活动期与非活动期TED患者同一参数的比较分析。TED组与健康组之间差异的平均值为38.79μm，置信区间（CI）为0.09至77.49μm（P = 0.0495）。活动期TED组与非活动期TED组之间的平均差异为38.02μm，CI为8.62至67.42μm（P = 0.0113）。所有结果均具有统计学意义。
