Yeh En-Ling, Yang Chun-Pai, Lin Shu-Wen, Wang Hsueh-Fang
Department of Nutrition, Hungkuang University, Taichung, Taiwan.
Department of Neurology, Kuang Tien General Hospital, Taichung, Taiwan.
Brain Behav. 2024 Dec;14(12):e70149. doi: 10.1002/brb3.70149.
Migraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients.
All subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers.
The average age of the 47 subjects in this study was 40.3 ± 9.2 years old, the body mass index (BMI) was 24.3 ± 6.0 kg/m. At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). Blood lipid indexes TC, LDL-C, and TG were reduced, and the frequency, duration, and pain degree of migraine.
Fish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.
偏头痛是一种慢性、复发性且致残性疾病。采用鱼油干预来研究其对偏头痛患者头痛症状和血脂的影响。
2020年3月至2021年5月期间，在匡田总医院收集所有受试者。实验组受试者在早餐和晚餐后服用1克/次的鱼油（每片含900毫克二十碳五烯酸）。安慰剂组受试者每日服用两次100%的大豆油。在测试前后，使用偏头痛改善问卷来分析发作期间的头痛情况、饮食摄入和头痛诱因。
本研究中47名受试者的平均年龄为40.3±9.2岁，体重指数（BMI）为24.3±6.0千克/米²。在第12周时，鱼油组受试者相对于对照组有显著改善（p<0.05）。血脂指标总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）降低，偏头痛的发作频率、持续时间和疼痛程度也降低。
鱼油可作为缓解偏头痛发作症状和血脂的辅助治疗性食物。
