School of Chemistry , University of St. Andrews , St. Andrews , KY16 9ST , United Kingdom.
Org Lett. 2018 May 4;20(9):2654-2658. doi: 10.1021/acs.orglett.8b00864. Epub 2018 Apr 19.
A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
一种锰催化的酯氢化反应已经实现，使用廉价、环境友好的碳酸钾和简单醇分别作为活化剂和溶剂，TON 值最高可达 1000。弱碱性条件导致良好的官能团耐受性，并使对映体富集的 α-手性酯的氢化基本上没有立体化学完整性的损失成为可能。
