2010 - 2015年对接受实验性外科手术的非人灵长类动物进行镇痛和麻醉药物给药的报告。
Reported analgesic and anaesthetic administration to non-human primates undergoing experimental surgical procedure: 2010-2015.
作者信息
Bertrand Henri Georges Michel Justin, Sandersen Charlotte, Flecknell Paul Andrew
机构信息
Department of Biomedical Services, University of Oxford, Oxford, UK.
Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.
出版信息
J Med Primatol. 2018 Apr 19. doi: 10.1111/jmp.12346.
BACKGROUND
The use of non-human primates (NHPs) in research remains a major societal concern with public expectations that appropriate anaesthetics and analgesics are used to minimize any pain or distress caused to animals undergoing invasive procedures. A literature review was conducted to examine the reporting of anaesthesia and analgesia methods used in non-human primates undergoing surgical procedures, with recovery from anaesthesia.
METHODS
A total of 397 papers from peer-review journals published between 2010 and 2015 were examined.
RESULTS
Only 25.9% of papers reported the analgesic regimen used, with carprofen and buprenorphine the 2 most widely used agents. Reporting of the anaesthetic regimens was included in 49.9% of papers. Ketamine and isoflurane were the most frequently used anaesthetic agents.
CONCLUSIONS
Anaesthetic and analgesic regimens administered to NHPs remain poorly reported. This lack of detailed descriptions of protocols does little to reassure the public or regulatory authorities that appropriate high standards of perioperative care are employed.
背景
在研究中使用非人类灵长类动物（NHPs）仍然是一个主要的社会关注点，公众期望使用适当的麻醉剂和镇痛药，以尽量减少对接受侵入性手术的动物造成的任何疼痛或痛苦。进行了一项文献综述，以检查在接受手术的非人类灵长类动物中使用的麻醉和镇痛方法以及麻醉恢复情况的报告。
方法
共检查了2010年至2015年间同行评审期刊上发表的397篇论文。
结果
只有25.9%的论文报告了所使用的镇痛方案，其中卡洛芬和丁丙诺啡是最广泛使用的两种药物。49.9%的论文包含了麻醉方案的报告。氯胺酮和异氟烷是最常用的麻醉剂。
结论
给予非人类灵长类动物的麻醉和镇痛方案的报告仍然很少。缺乏对方案的详细描述无助于让公众或监管机构放心，即采用了适当的高标准围手术期护理。
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