Department of Haematology, Salisbury NHS Foundation Trust, Salisbury, UK.
Department of Haematology, Gartnaval General Hospital, Glasgow, UK.
Br J Haematol. 2018 May;181(3):331-340. doi: 10.1111/bjh.15166. Epub 2018 Apr 19.
Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.
血清铁蛋白水平是初级和二级保健中最常要求进行的检查之一。虽然血清铁蛋白水平低通常表明铁储存减少，但血清铁蛋白水平升高可能是由于多种不同的病因引起的，包括铁过载、炎症、肝脏或肾脏疾病、恶性肿瘤以及最近描述的代谢综合征。进一步检查意外升高的血清铁蛋白的关键测试是血清转铁蛋白饱和度。本指南回顾了升高的血清铁蛋白水平的检查和管理。然而，并未涉及遗传性血色素沉着症的检查和管理，这是另一个指南的主题。
