Fetal i+d Fetal Medicine Research Centre, BCNatal - Barcelona Centre for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic of Gynecology, Obstetrics and Neonatology, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain.
Fetal Medicine Mexico, Fetal Medicine and Surgery Research Unit, Children and Women's Specialty Hospital, Instituto de Neurobiología, Unidad de Investigación en Neurodesarrollo, Universidad Nacional Autónoma de México (UNAM), Queretaro, Mexico.
BJOG. 2019 Jan;126(2):291-298. doi: 10.1111/1471-0528.15246. Epub 2018 Jun 13.
To assess the postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies (ART) in children at 3 years of age.
A cohort study of children conceived by ART.
Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain.
Eighty singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood.
Cardiovascular evaluation was performed at 3 years of corrected age, including echocardiography, carotid intima-media (cIMT) by ultrasound, and blood pressure.
Postnatal persistence of cardiovascular changes in children conceived by ART.
Compared with controls, children conceived by ART showed larger atria (right atrial area: control 4.9 cm (0.9) versus ART 5.5 cm (0.9), P < 0.001), more globular ventricles (right ventricular sphericity index: control mean 1.8 (SD 0.5) versus ART 1.6 (0.2), P < 0.001), and signs of systolic (tricuspid annular plane systolic excursion: control 18 mm (2) versus ART 16 mm (3), P < 0.001) and diastolic dysfunction (isovolumic relaxation time: control 68 ms (12) versus ART 79 ms (12), P < 0.001). ART children also presented increased systolic blood pressure (control 90 mmHg (6) versus ART 94 mmHg (5), P < 0.003) and cIMT (control 0.52 μm (0.14) versus ART 0.60 μm (0.16), P < 0.001) as compared with those spontaneously conceived.
Cardiovascular changes previously reported in ART fetuses persist postnatally at 3 years of age. These results underscore the importance of future studies for assessing the long-term cardiovascular health associated with ART.
Cardiovascular changes described in fetuses conceived by ART, persist in children at 3 years of age.
评估与辅助生殖技术（ART）相关的胎儿心血管重塑在 3 岁儿童中的产后持续性。
ART 受孕儿童的队列研究。
西班牙巴塞罗那 Clinic 医院母胎医学科。
80 例通过 ART 受孕的单胎妊娠和 80 例自然受孕（对照组）的妊娠，从胎儿期一直随访到儿童期。
在 3 年的校正年龄时进行心血管评估，包括超声心动图、颈动脉内膜-中层（cIMT）和血压。
ART 受孕儿童的心血管变化的产后持续性。
与对照组相比，ART 受孕的儿童的心房更大（右心房面积：对照组 4.9cm（0.9）与 ART 组 5.5cm（0.9），P＜0.001），心室更球形（右心室球形指数：对照组平均值 1.8（0.5）与 ART 组 1.6（0.2），P＜0.001），以及收缩期（三尖瓣环平面收缩期位移：对照组 18mm（2）与 ART 组 16mm（3），P＜0.001）和舒张功能障碍（等容舒张时间：对照组 68ms（12）与 ART 组 79ms（12），P＜0.001）的迹象。ART 儿童的收缩压（对照组 90mmHg（6）与 ART 组 94mmHg（5），P＜0.003）和 cIMT（对照组 0.52μm（0.14）与 ART 组 0.60μm（0.16），P＜0.001）也高于自然受孕的儿童。
先前在 ART 胎儿中报道的心血管变化在 3 岁时仍持续存在。这些结果强调了未来研究评估与 ART 相关的长期心血管健康的重要性。
ART 受孕胎儿中描述的心血管变化在 3 岁儿童中持续存在。
