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辅助生殖技术受孕子代心血管系统的超声评估。

Ultrasound evaluation of the cardiovascular system in offspring conceived through assisted reproductive technology.

机构信息

Department of Medical Ultrasound, Huazhong University of Science and Technology Tongji Medical College Tongji Hospital, Wuhan, 430030, China.

出版信息

J Assist Reprod Genet. 2024 Mar;41(3):623-634. doi: 10.1007/s10815-024-03029-5. Epub 2024 Jan 20.

Abstract

With the widespread application of assisted reproductive technology, the health issues of offspring conceived through assisted reproductive technology have also received increasing attention. Animal experiments and clinical studies have found subclinical adverse changes in the cardiovascular system of assisted reproductive offspring. Assisted reproductive technology itself may be just one of the many factors contributing to this phenomenon, with epigenetics playing an important role. Ultrasound technology can be used to assess the morphological structure and function of the cardiovascular system in assisted reproductive offspring from the fetal stage, providing the possibility to study the potential cardiovascular damage in this large population. This review aims to explore the effects and mechanisms of assisted reproductive technology on the cardiovascular system of offspring and provide a review of the research progress in ultrasound technology in this area.

摘要

随着辅助生殖技术的广泛应用,通过辅助生殖技术受孕的后代的健康问题也受到了越来越多的关注。动物实验和临床研究发现,辅助生殖后代的心血管系统存在亚临床不良改变。辅助生殖技术本身可能只是导致这一现象的众多因素之一,而表观遗传学则起着重要作用。超声技术可用于从胎儿期评估辅助生殖后代的心血管系统的形态结构和功能,为研究这一大人群潜在的心血管损害提供了可能。本综述旨在探讨辅助生殖技术对后代心血管系统的影响及其机制,并对该领域超声技术的研究进展进行综述。

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[Diseases of offspring conceived by assisted reproductive technology and epigenetics].[辅助生殖技术受孕子代的疾病与表观遗传学]
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本文引用的文献

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Can Surrogate Markers Help Define Cardiovascular Disease in Youth?替代标志物能否帮助界定青年人心血管疾病?
Curr Atheroscler Rep. 2023 Jun;25(6):275-298. doi: 10.1007/s11883-023-01101-6. Epub 2023 May 6.
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Fetal cardiac function at midgestation and conception by in-vitro fertilization.中孕期胎儿心功能与体外受精受孕。
Ultrasound Obstet Gynecol. 2023 May;61(5):587-592. doi: 10.1002/uog.26207. Epub 2023 Apr 7.

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