Instituto de Química, Universidad de Antioquia, Medellín 050010, Colombia.
Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia.
Molecules. 2018 Apr 17;23(4):934. doi: 10.3390/molecules23040934.
A new alkaloid, Canthin-6-one, Huberine (), together with three known compounds including 1-Hydroxy-canthin-6-one (), Canthin-6-one () and stigma sterol (), were isolated from the stem bark of . The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, /) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied.
从 中分离得到一个新的生物碱 Canthin-6-one, Huberine ()，以及三个已知化合物，包括 1-Hydroxy-canthin-6-one ()、Canthin-6-one () 和 stigmasterol ()。通过色谱技术进行分离，采用 C18 柱，以乙腈/水（90:10，/）为流动相，用 0.1%甲酸作为流动相，进行纯化。通过光谱方法，特别是 1D-和 2D-NMR、UV、IR、MS 和 HRMS，进行了结构鉴定。研究了化合物的抗疟活性。
