Pabón Adriana, Ramirez Otoniel, Ríos Alexandra, López Ena, de Las Salas Briegel, Cardona Felipe, Blair Silvia
Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Herbario Universidad de Antioquia, Medellín, Colombia.
Planta Med. 2016 May;82(8):717-22. doi: 10.1055/s-0042-104283. Epub 2016 Apr 28.
The in vitro antiplasmodial activity of 122 raw extracts prepared in ethanol and water from 35 medicinal plants reported by the Cubeo indigenous village of the Amazon region (Vaupés Medio in Colombia) was evaluated for efficacy against 3D7 (sensitive to chloroquine) and FCR-3 (resistant to chloroquine) Plasmodium falciparum strains. Five percent of these extracts presented a significant antiplasmodial activity (< 5 µg/mL) and 83 % of them were not cytotoxic. These findings highlight the importance of investigating traditional medicinal plants implemented by these ancestral communities of the Amazon region as well as their potential to become a source of new drugs against malaria.
对来自亚马逊地区（哥伦比亚沃佩斯省中部）库贝奥原住民村报告的35种药用植物用乙醇和水制备的122种粗提物的体外抗疟原虫活性进行了评估，以检测其对3D7（对氯喹敏感）和FCR-3（对氯喹耐药）恶性疟原虫菌株的疗效。这些提取物中有5%呈现出显著的抗疟原虫活性（<5μg/mL），其中83%没有细胞毒性。这些发现凸显了研究亚马逊地区这些古老社区所使用的传统药用植物的重要性，以及它们成为抗疟疾新药来源的潜力。
