成年人囊性纤维化患者的动态过度充气是否会影响日常体力活动？
Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?
机构信息
Department of Public Health and Infectious Diseases, Adult Cystic Fibrosis Center, Sapienza University of Rome, 00185, Rome, Italy.
Cystic Fibrosis Unit, Bambino Gesù Children's Hospital, Rome, Italy.
出版信息
BMC Pulm Med. 2018 Apr 19;18(1):60. doi: 10.1186/s12890-018-0623-7.
BACKGROUND
The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).
METHODS
Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related measurements included: oxygen uptake (V'O), carbon dioxide production (V'CO), ventilatory profile, work rate (W), inspiratory capacity (IC), end-expiratory lung volume (EELV). PA was assessed using the accelerometer SenseWear Pro3 Armband.
RESULTS
Exercise tolerance was reduced in most of patients and the mean V'O value was 75.2% of predicted (28.5 ± 4.8 ml/min/kg). Seventy % of patients responded to CPET with dynamic hyperinflation. Higher incidence of dynamic hyperinflation was found in CF males compared to CF females (p = 0.026). Patients who developed dynamic hyperinflation during CPET had higher vigorous PA (p = 0.01) and more total energy expenditure (p = 0.006) than patients who did not. EELVΔ was related to activities requiring vigorous intensity and total energy expenditure (R = 0.46, p = 0.001; R = 0.57, p < 0.001).
CONCLUSIONS
In adults with CF and mild to moderate lung impairment, DPA might not be limited by dynamic hyperinflation.
背景
本研究旨在探讨成人囊性纤维化（CF）患者动态过度充气与日常体力活动（DPA）之间的关系。
方法
对 34 例临床稳定的 CF 患者进行研究。所有患者均进行增量心肺运动测试（CPET）。CPET 相关测量包括：摄氧量（V'O）、二氧化碳产生量（V'CO）、通气模式、功量（W）、吸气容量（IC）、呼气末肺容积（EELV）。使用加速度计 SenseWear Pro3 臂带评估 PA。
结果
大多数患者的运动耐量降低，平均 V'O 值为预计值的 75.2%（28.5±4.8 ml/min/kg）。70%的患者对 CPET 有动态过度充气反应。CF 男性患者动态过度充气的发生率高于 CF 女性患者（p=0.026）。在 CPET 期间发生动态过度充气的患者，剧烈体力活动（p=0.01）和总能量消耗（p=0.006）更高。EELVΔ与需要剧烈强度的活动和总能量消耗相关（R=0.46，p=0.001；R=0.57，p<0.001）。
结论
在轻度至中度肺损伤的 CF 成人中，DPA 可能不受动态过度充气的限制。
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