Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
Liaquat National Hospital and Medical College, Karachi, Pakistan.
World J Surg Oncol. 2018 Apr 19;16(1):81. doi: 10.1186/s12957-018-1385-7.
The rationale behind this study was to find out the frequency of dysplasia and colorectal cancer (CRC) in young patients with ulcerative colitis (UC) using histopathological examination. This facilitated early detection of dysplasia and CRC by regular endoscopic biopsies and also guided physicians on appropriate surveillance and management, thus improved outcome.
It was a prospective cross-sectional study conducted at the Department of Pathology, PIMS, Islamabad. Seventy-six biopsies of already diagnosed cases of UC of young patients aged between 15 and 40 years of either gender were included. Specimens were fixed in 10% buffer formalin, paraffin embedded followed by cutting, slide preparation, and staining with hematoxylin and eosin (H&E) stain, and examined under light microscope. Statistical package for social sciences (SPSS 21) was used for data compilation and analysis. Mean and standard deviation were calculated for quantitative variables. Frequency and percentage were calculated for qualitative variables.
There were 13 (17.2%) patients who were diagnosed with colorectal dysplasia, 3 (4.0%) with indefinite for dysplasia, 8 (10.5%) with low-grade dysplasia, and 2 (2.6%) with high-grade dysplasia. There were three (3.9%) patients who were diagnosed for colorectal carcinoma, one (1.3%) with grade 1, one (1.3%) with grade 2, and one (1.3%) with grade 3 CRC.
Routine biopsies can identify dysplastic epithelium, which is an established sign for synchronized carcinoma with ulcerative colitis, and give the rationale for surveillance of the patients.
本研究的基本原理是通过组织病理学检查确定溃疡性结肠炎（UC）年轻患者中发育不良和结直肠癌（CRC）的频率。这通过定期内镜活检实现了对发育不良和 CRC 的早期发现，并指导医生进行适当的监测和管理，从而改善了结果。
这是在伊斯兰堡 PIMS 病理学系进行的一项前瞻性横断面研究。纳入了年龄在 15 至 40 岁之间的年轻患者中已经诊断为 UC 的 76 例活检标本，无论性别如何。将标本用 10%缓冲福尔马林固定，石蜡包埋，然后进行切片、准备玻片，并使用苏木精和伊红（H&E）染色进行染色，在光学显微镜下进行检查。使用社会科学统计软件包（SPSS 21）进行数据汇编和分析。对定量变量计算平均值和标准差。对定性变量计算频率和百分比。
有 13 例（17.2%）患者被诊断为结直肠发育不良，3 例（4.0%）为发育不良不确定，8 例（10.5%）为低级别发育不良，2 例（2.6%）为高级别发育不良。有 3 例（3.9%）患者被诊断为结直肠癌，1 例（1.3%）为 1 级，1 例（1.3%）为 2 级，1 例（1.3%）为 3 级 CRC。
常规活检可以识别发育不良的上皮细胞，这是溃疡性结肠炎同步癌的既定标志，并为患者的监测提供了依据。
