中国新疆维吾尔自治区健康人群中肺炎链球菌携带情况的横断面调查。
A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China.
机构信息
Department of Public Health, Xinjiang Medical University, Urumqi 830054, Xinjiang, China; National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
Medical Laboratory Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China.
出版信息
Biomed Environ Sci. 2018 Mar;31(3):233-237. doi: 10.3967/bes2018.029.
The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88.6%), which merits further attention. The co-colonization rate of two or more S. pneumoniae serotypes was 79.8% (264/331). This study aimed to investigate the baseline pneumococcal carriage rate among healthy individuals in China to improve our understanding of the epidemiology of S. pneumoniae.
在中国健康人群中，肺炎链球菌（Streptococcus pneumoniae，S. pneumoniae）的携带率和血清型分布尚不清楚。本研究采集了中国新疆地区 513 名个体的咽拭子标本。采用针对 lytA 基因和 12 种血清型的实时 PCR 方法来鉴定 S. pneumoniae 的携带情况。S. pneumoniae 的总携带率为 70.4%（361/513）。最常见的血清型为 19B/F、18B/C、5 和 6A/B。6-10 岁儿童的 S. pneumoniae 携带率最高（88.6%），值得进一步关注。两种或多种 S. pneumoniae 血清型的共同定植率为 79.8%（264/331）。本研究旨在调查中国健康个体中肺炎链球菌的基线携带率，以加深我们对 S. pneumoniae 流行病学的认识。
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