Wang Xu-Lin, Cehn Min-Qi, Li Wen-Yu, Fu Jin-Jian, Ye Xiao-Hua
School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2021 Apr;23(4):363-368. doi: 10.7499/j.issn.1008-8830.2011078.
To study the clustering and influencing factors of carriage among kindergarten children, and to provide a scientific basis for the prevention of pneumococcal diseases.
The multi-stage stratified cluster sampling method was used to collect nasal swabs via the nasal vestibule at both sides from 1 702 kindergarten children in Liuzhou, China. A questionnaire survey was performed on their parents. The chi-square test and the random effects logistic regression analysis were used to analyze data.
The carriage rate of was 13.16% (224/1 702) among kindergarten children. The clustering analysis showed that the class-level random effect of carriage was statistically significant (=2.07, =0.038), with an intraclass correlation coefficient of 5.9%. The random effects logistic regression analysis showed that the children aged 5-7 years had a lower risk of carriage than those aged 2-< 5 years (=0.55, 95%:0.40-0.76, =0.001), and the children with ≥ 5 family members living together had a higher risk of carriage than those with < 5 family members (=1.34, 95%:1.01-1.79, =0.043).
carriage shows a class-level clustering effect, and age and the number of cohabitants are important influencing factors for carriage in children.
研究幼儿园儿童肺炎链球菌携带情况的聚集性及影响因素，为预防肺炎链球菌疾病提供科学依据。
采用多阶段分层整群抽样方法，对中国柳州市1702名幼儿园儿童双侧鼻前庭采集鼻拭子，并对其家长进行问卷调查。采用卡方检验和随机效应logistic回归分析进行数据分析。
幼儿园儿童肺炎链球菌携带率为13.16%（224/1702）。聚类分析显示，肺炎链球菌携带的班级水平随机效应具有统计学意义（χ² = 2.07，P = 0.038），组内相关系数为5.9%。随机效应logistic回归分析显示，5至7岁儿童肺炎链球菌携带风险低于2至<5岁儿童（OR = 0.55，95%CI：0.40 - 0.76，P = 0.001），与<5名家庭成员共同居住的儿童肺炎链球菌携带风险高于与≥5名家庭成员共同居住的儿童（OR = 1.34，95%CI：1.01 - 1.79，P = 0.043）。
肺炎链球菌携带呈现班级水平聚集效应，年龄和同居人数是儿童肺炎链球菌携带的重要影响因素。
