Takagi Hiroaki, Sasagawa Toshiyuki, Shibata Takeo, Minato Hiroshi, Takahashi Tomoko
Department of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, Japan.
Department of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, Japan.
Taiwan J Obstet Gynecol. 2018 Apr;57(2):283-288. doi: 10.1016/j.tjog.2018.02.018.
The incidence of endometrial adenocarcinoma of the uterine corpus has increased in Japan. This study aimed to clarify the relationships between this type of cancer and various data provided by 18F-fluorodeoxyglucose (FDG) accumulation in positron emission tomography/computed tomography (PET/CT).
The study cohort thus comprised 27 patients with endometrial adenocarcinoma who had undergone PET/CT examinations from April 2008 to March 2015. All patients provided informed consent at our hospital. Data from 27 patients with endometrial adenocarcinoma (Grades 1-3) were retrospectively analyzed to determine the relationships between the maximum standardized uptake value (SUVmax), histological grading, tumor size, and rate of positivity for glucose transporter 1, hexokinase II, and glucose-6-phosphatase-α (G6Pase-α).
SUVmax values differed significantly between patients with Grade 1 (G1) and Grade 2 (G2) or higher cancer (P = 0.031). For G1 cancer, a negative correlation was found between SUVmax and G6Pase-α (R = -0.475, P = 0.046). The regression coefficient for G6Pase-α was -0.125 (95% CI: -0.165 to -0.084) and the P-value 0.008; thus this difference was significant.
PET/CT is a useful test for discriminating between G1 and G2 or higher cancer in patients with endometrial adenocarcinoma of the uterine corpus. In addition, the negative correlation identified between SUVmax and G6Pase-α activity in patients with well-differentiated endometrial cancer may be a novel finding.
日本子宫体子宫内膜腺癌的发病率有所上升。本研究旨在阐明这种癌症与正电子发射断层扫描/计算机断层扫描（PET/CT）中18F-氟脱氧葡萄糖（FDG）摄取所提供的各种数据之间的关系。
本研究队列包括2008年4月至2015年3月期间接受PET/CT检查的27例子宫内膜腺癌患者。所有患者均在我院签署了知情同意书。对27例子宫内膜腺癌（1-3级）患者的数据进行回顾性分析，以确定最大标准化摄取值（SUVmax）、组织学分级、肿瘤大小以及葡萄糖转运蛋白1、己糖激酶II和葡萄糖-6-磷酸酶-α（G6Pase-α）的阳性率之间的关系。
1级（G1）和2级（G2）或更高级别癌症患者的SUVmax值存在显著差异（P = 0.031）。对于G1级癌症，发现SUVmax与G6Pase-α之间存在负相关（R = -0.475，P = 0.046）。G6Pase-α的回归系数为-0.125（95%CI：-0.165至-0.084），P值为0.008；因此，这种差异具有显著性。
PET/CT对于鉴别子宫体子宫内膜腺癌患者的G1级和G2级或更高级别癌症是一种有用的检查方法。此外，在高分化子宫内膜癌患者中发现的SUVmax与G6Pase-α活性之间的负相关可能是一项新发现。
