Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510275, China; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Department of Hematology, Harbin Medical University, Affiliated Hospital 1, Harbin 150001, Heilongjiang, China.
Talanta. 2018 Jul 1;184:446-451. doi: 10.1016/j.talanta.2018.03.021. Epub 2018 Mar 14.
Arsenic in hair and nails has been used to assess chronic exposure of humans to environmental arsenic. However, it remains to be seen whether it is appropriate to evaluate acute exposure to sub-lethal doses of arsenic typically used in therapeutics. In this study, hair, fingernail and toenail samples were collected from nine acute promyelocytic leukemia (APL) patients who were administered intravenously the daily dose of 10 mg arsenic trioxide (7.5 mg arsenic) for up to 54 days. These hair and nail samples were analyzed for arsenic species using high performance liquid chromatography separation and inductively coupled plasma mass spectrometry detection (HPLC-ICPMS). Inorganic arsenite was the predominant form among water-extractable arsenicals. Dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), monomethylarsonous acid (MMA), monomethylmonothioarsonic acid (MMMTA), and dimethylmonothioarsinic acid (DMMTA) were also detected in both hair and nail samples. This is the first report of the detection of MMA and MMMTA as metabolites of arsenic in hair and nails of APL patients.
头发和指甲中的砷已被用于评估人类对环境砷的慢性暴露。然而，目前尚不清楚评估亚致死剂量砷（通常用于治疗）的急性暴露是否合适。在这项研究中，收集了 9 名急性早幼粒细胞白血病（APL）患者的头发、指甲和趾甲样本，这些患者每天静脉注射 10mg 三氧化二砷（7.5mg 砷），最多持续 54 天。使用高效液相色谱分离和电感耦合等离子体质谱检测法（HPLC-ICPMS）分析这些头发和指甲样本中的砷形态。在可溶于水的砷化物中，亚砷酸盐是主要形式。在头发和指甲样本中还检测到二甲基砷酸（DMA）、一甲基砷酸（MMA）、一甲基砷酸（MMA）、一甲基单硫代砷酸（MMMTA）和二甲基单硫代砷酸（DMMTA）。这是首次在 APL 患者的头发和指甲中检测到 MMA 和 MMMTA 作为砷的代谢物的报告。
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