Zidane Monia, Ren Yen, Xhaard Constance, Leufroy Axelle, Côte Suzanne, Dewailly Eric, Noël Laurent, Guérin Thierry, Bouisset Patrick, Bernagout Solène, Paaoafaite John, Iltis Jacques, Taquet Marc, Suhas Eric, Rachédi Frédérique, Boissin Jean Louis, Sebbag Joseph, Shan Larrys, Bost-Bezeaud Frédérique, Petitdidier Patrice, Rubino Carole, Gardon Jacques, de Vathaire Florent
Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP), UMR 1018 Inserm, Villejuif, France.
Gustave Roussy, Villejuif, France.
Asian Pac J Cancer Prev. 2019 Feb 26;20(2):355-367. doi: 10.31557/APJCP.2019.20.2.355.
Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association between thyroid cancer risk and daily intake levels of nETE and with fingernail nETE levels. Results: Hg contamination was mainly present in sea products, Pb contamination was present in almost all samples, Cd was detectable in starchy food and As was detectable in all sea products. No patient exceeded dietary contamination WHO limits for Pb, 2 participants exceeded it for Hg and 3 individuals (0.5%) for cadmium. In fingernail clippings, the most detectable pollutant was Pb (553 participants), then Hg (543 participants) then Cd (only in 130 participants). Thyroid cancer risk was increased more than 4 times by Pb daily intake in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.01), and 2 times more in women with more than 3 pregnancies than in those with none or less (p for interaction =0.005); it was also increased following As intake by more than 30% in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.05). Conclusion: Locally produced foods are not a source of nETE exposure in French Polynesia. Dieatry nETE exposure and fingernail nETE concentration are not associated to differentiated thyroid cancer risk. No correlation found between nETE dietary exposure and fingernail nETE concentration.
据报道，法属波利尼西亚的甲状腺癌死亡率和发病率位居世界之首。体内非必需微量元素（nETE）水平过高与多种癌症相关。目的：本研究旨在提供法属波利尼西亚食物中汞（Hg）、铅（Pb）、砷（As）和镉（Cd）污染的定量信息及其与波利尼西亚人指甲检测结果的潜在相关性，进而调查这些nETE与不同甲状腺癌风险之间的潜在关联。方法：研究人群包括229名受访病例和373名受访对照。我们对波利尼西亚食物进行了描述性分析，并研究了甲状腺癌风险与nETE每日摄入量以及指甲nETE水平之间的关联。结果：汞污染主要存在于海产品中，铅污染几乎存在于所有样本中，镉在淀粉类食物中可检测到，砷在所有海产品中均可检测到。没有患者的膳食铅污染超过世界卫生组织的限值，2名参与者的汞污染超标，3名个体（0.5%）的镉污染超标。在指甲剪屑中，最易检测到的污染物是铅（553名参与者），其次是汞（543名参与者），然后是镉（仅130名参与者）。有一级亲属癌症病史的患者，铅每日摄入量使甲状腺癌风险增加的幅度比无此病史的患者高出4倍多（交互作用p值 = 0.01），怀孕3次以上的女性比未怀孕或怀孕次数较少的女性高出2倍多（交互作用p值 = 0.005）；有一级亲属癌症病史的患者，砷摄入量使甲状腺癌风险增加的幅度比无此病史的患者高出30%以上（交互作用p值 = 0.05）。结论：法属波利尼西亚当地生产的食物不是nETE暴露的来源。膳食nETE暴露和指甲nETE浓度与分化型甲状腺癌风险无关。未发现nETE膳食暴露与指甲nETE浓度之间存在相关性。
