Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
School of Pharmacy, China Medical University, Taichung, 406040, Taiwan.
Anal Sci. 2022 Feb;38(2):247-260. doi: 10.2116/analsci.21SAR06. Epub 2022 Mar 22.
The growth of illicit drugs is a serious social problem, putting great pressure on law enforcement officers to screen numerous suspicious samples at crime scenes. Although commercial colorimetric kits are available, they are limited to common illicit drugs. With increasing numbers of new psychoactive substances in the market, accurate and rapid screening assays are highly demanded. Carbon dots (C-dots) are photoluminescent (PL) carbon nanomaterials with unique properties of excellent stability against salt and photo-irradiation, low blinking, and biocompatibility. They can be prepared easily through various routes from numerous precursors. This Focus provides examples of C-dots based PL assays for screening illicit drugs. The drugs induce PL changes of C-dots mostly through electron transfer and energy transfer. Liquid- and solid-phase PL assays of C-dots can be applied for in-field screening, with advantages of rapidity, low cost, selectivity, and minimum color interference, showing their great commercial potential.
非法药物的增长是一个严重的社会问题，这给执法人员带来了巨大的压力，需要在犯罪现场筛选大量可疑样本。尽管有商用比色试剂盒，但它们仅限于常见的非法药物。随着市场上新精神活性物质数量的增加，对准确和快速的筛选方法的需求也越来越高。碳点（C-dots）是具有独特性质的光致发光（PL）碳纳米材料，具有出色的耐盐性和耐光照射性、低闪烁性和生物相容性。它们可以通过多种途径从众多前体制备而成。本专题提供了基于 C-dots 的 PL 分析用于筛选非法药物的示例。这些药物主要通过电子转移和能量转移诱导 C-dots 的 PL 变化。液体和固相 C-dots 的 PL 分析可用于现场筛选，具有快速、低成本、选择性和最小颜色干扰的优点，显示出其巨大的商业潜力。
