Microenvironmental M1 tumor-associated macrophage polarization influences cancer-related anemia in advanced ovarian cancer: key role of interleukin-6.
作者信息
Madeddu Clelia, Gramignano Giulia, Kotsonis Paraskevas, Coghe Ferdinando, Atzeni Vinicio, Scartozzi Mario, Macciò Antonio
机构信息
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Medical Oncology Unit, San Gavino Hospital, San Gavino.
出版信息
Haematologica. 2018 Sep;103(9):e388-e391. doi: 10.3324/haematol.2018.191551. Epub 2018 Apr 19.
Abstract
摘要
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Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6-producing lung carcinoma cells.用抗白细胞介素-6受体抗体治疗可防止接种产生白细胞介素-6的肺癌细胞的小鼠血清铁调素水平升高，并改善贫血症状。
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The iron-regulatory hormone hepcidin: a possible therapeutic target?铁调节激素——hepcidin：一种可能的治疗靶点？
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Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.巨噬细胞的代谢重编程：葡萄糖转运蛋白 1（GLUT1）介导的葡萄糖代谢驱动促炎表型。
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