Yang Min, Wang Min, Li Xianping, Xie Yixin, Xia Xiaomeng, Tian Jingjing, Zhang Kan, Tang Aiguo
Department of Laboratory Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
J Cancer. 2018 Mar 20;9(7):1277-1286. doi: 10.7150/jca.22005. eCollection 2018.
Cervical cancer (CC) is the second most common malignant cancer in women. CC is difficult to diagnose, has a high recurrence rate, and is resistant to systemic therapies; as a result, CC patients have a relatively poor prognosis. One potential link to CC is the Wnt signaling pathway and its downstream effectors, which regulate cell differentiation, proliferation, migration, and fate. The aberrant activation of Wnt signaling is associated with various cancers, including CC. Recent studies have shown that activating or inhibiting the intracellular signal transduction in this pathway can regulate cancer cell growth and viability. This review will summarize the experimental evidence supporting the significance of the Wnt signaling pathway in CC, and will also discuss the current clinical role of Wnt signaling in CC diagnosis, therapy, and prognosis.
宫颈癌（CC）是女性中第二常见的恶性肿瘤。宫颈癌难以诊断，复发率高，且对全身治疗耐药；因此，宫颈癌患者的预后相对较差。与宫颈癌的一个潜在联系是Wnt信号通路及其下游效应分子，它们调节细胞分化、增殖、迁移和命运。Wnt信号的异常激活与包括宫颈癌在内的多种癌症相关。最近的研究表明，激活或抑制该通路中的细胞内信号转导可以调节癌细胞的生长和活力。本综述将总结支持Wnt信号通路在宫颈癌中重要性的实验证据，并讨论Wnt信号在宫颈癌诊断、治疗和预后方面的当前临床作用。
