结构与血管光学相干断层扫描相结合用于鉴别处于不同致癌阶段的小鼠口腔病变
Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages.
作者信息
Chen Ping-Hisen, Wu Chien-Hsien, Chen Yi-Fen, Yeh Yi-Chen, Lin Bo-Han, Chang Kuo-Wei, Lai Pei-Yu, Hou Ming-Chih, Lu Ching-Liang, Kuo Wen-Chuan
机构信息
Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Faculty of Medicine, School of Medicine National Yang-Ming University School, Taipei 112, Taiwan.
出版信息
Biomed Opt Express. 2018 Mar 2;9(4):1461-1476. doi: 10.1364/BOE.9.001461. eCollection 2018 Apr 1.
Abstract
Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4- nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.
摘要
使用当前的光学工具难以区分口腔中的早期恶性肿瘤和良性病变。如先前研究所示，鳞状上皮中的微血管变化可被视为诊断的关键标志物。我们建议将结构和血管光学相干断层扫描（OCT）成像相结合，以研究疾病相关变化。在4-硝基喹啉-1-氧化物（4NQO）小鼠模型的癌症发展过程中，观察到上皮的渐进性厚度变化和下方固有层的破坏。同时，观察到增生、发育异常、原位癌和晚期癌症中的微血管变化。将OCT成像的结果与组织学结果进行了比较。
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