Zhu Yunhao, Johnson Laura A, Huang Ziyi, Rubin Jonathan M, Yuan Jie, Lei Hao, Ni Jun, Wang Xueding, Higgins Peter D R, Xu Guan
Department of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu 21000, China.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Biomed Opt Express. 2018 Mar 8;9(4):1590-1600. doi: 10.1364/BOE.9.001590. eCollection 2018 Apr 1.
Crohn's disease (CD) is a chronic autoimmune disease characterized by obstructing intestinal strictures. Conventional imaging modalities can identify the strictures but cannot characterize whether a stricture is predominantly inflammatory or fibrotic. The purpose of this study is to examine the capability of photoacoustic (PA) imaging to characterize intestinal fibrosis and inflammation . Intestinal strictures in a rat model of CD were imaged with a PA-ultrasound parallel imaging system. Internal and external illuminations were attempted, both with transcutaneous PA signal reception. The PA signal magnitudes acquired at wavelengths targeting individual molecular components and the derived functional information showed significant differences between the inflammatory and fibrotic strictures, consistent with histological inflammation and fibrosis.
克罗恩病（CD）是一种以肠道狭窄梗阻为特征的慢性自身免疫性疾病。传统成像方式能够识别狭窄，但无法判定狭窄主要是炎症性还是纤维化性的。本研究的目的是检验光声（PA）成像鉴别肠道纤维化和炎症的能力。使用PA-超声并行成像系统对CD大鼠模型的肠道狭窄进行成像。尝试了内部和外部照明，并均采用经皮PA信号接收。在针对各个分子成分的波长处采集的PA信号强度以及获得的功能信息显示，炎症性狭窄和纤维化性狭窄之间存在显著差异，与组织学炎症和纤维化情况一致。
