Zhu Yunhao, Ni Linyu, Hu Guorong, Johnson Laura A, Eaton Kathryn A, Wang Xueding, Higgins Peter D R, Xu Guan
Department of Biomedical Engineering, University of Michigan, USA.
Department of Internal Medicine, University of Michigan, USA.
Biomed Opt Express. 2022 May 12;13(6):3355-3365. doi: 10.1364/BOE.456672. eCollection 2022 Jun 1.
In our previous studies, we have demonstrated the feasibility of characterizing intestinal inflammation and fibrosis using endoscopic photoacoustic imaging. Purposed at te clinical translation of the imaging technology, we developed a photoacoustic/ultrasound imaging probe by integrating a miniaturized ultrasound array and an angle-tipped optical fiber in a hydrostatic balloon catheter. When collapsed, the catheter probe may potentially be compatible with a clinical ileo-colonoscope. In addition, the flexible surface of the hydrostatic balloon allows for acoustic coupling at the uneven surfaces of the gas-filled intestine. Tissue phantom studies show that the catheter probe possesses an imaging penetration of at least 12 mm. Experiments with a rabbit model validated the probe in differentiating normal, acute and chronic conditions in intestinal obstruction.
在我们之前的研究中，我们已经证明了使用内镜光声成像来表征肠道炎症和纤维化的可行性。为了将该成像技术临床转化，我们通过将小型化超声阵列和角形光纤集成到一个静水压球囊导管中，开发了一种光声/超声成像探头。当导管探头收缩时，它有可能与临床回结肠镜兼容。此外，静水压球囊的柔性表面允许在充满气体的肠道不平表面进行声学耦合。组织仿体研究表明，该导管探头的成像穿透深度至少为12毫米。在兔模型上进行的实验验证了该探头在区分肠梗阻的正常、急性和慢性情况方面的有效性。
