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Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment.

作者信息

Gailhouste Luc, Liew Lee Chuen, Yasukawa Ken, Hagiwara Keitaro, Iwazaki Norihiko, Yamada Yasuhiro, Hatada Izuho, Ochiya Takahiro

机构信息

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.

Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):454-457.e1. doi: 10.1016/j.jcmgh.2017.11.006. eCollection 2018 Mar.

DOI:10.1016/j.jcmgh.2017.11.006
PMID:29675460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5904034/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/22813d4ac67c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/6d100e08dbfb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/edf272bdd4da/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/22813d4ac67c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/6d100e08dbfb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/edf272bdd4da/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb84/5904034/22813d4ac67c/fx1.jpg

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Epigenetic reprogramming modulates malignant properties of human liver cancer.表观遗传重编程调节人类肝癌的恶性特性。
Hepatology. 2014 Jun;59(6):2251-62. doi: 10.1002/hep.27026. Epub 2014 May 1.
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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.DNA甲基转移酶抑制剂地西他滨对异柠檬酸脱氢酶1(IDH1)突变型胶质瘤细胞分化的高效诱导及生长抑制作用
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J Funct Biomater. 2020 Mar 14;11(1):17. doi: 10.3390/jfb11010017.
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Cancer Sci. 2020 Mar;111(3):869-880. doi: 10.1111/cas.14292. Epub 2020 Jan 25.
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MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells.MEG3 衍生的 miR-493-5p 克服了肝癌细胞中 IGF2-miR-483 印迹缺失的致癌特征。
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