Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study.

BACKGROUND

Granulocyte colony-in stimulating factor () gene can be a potential candidate gene implicated recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age.

OBJECTIVE

To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of gene and the risk of unexplained RPL among Iranian women.

MATERIALS AND METHODS

In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. Tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects.

RESULTS

Statistically significant differences were detected between the distribution frequencies of both heterozygote CT, and carriage of T allele (TT+CT) genotypes of the rs1042658 between case and control groups. Allelic association was not observed with RPL.

CONCLUSION

Regarding the results of the present study, rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained RPL among Iranian women.