Nasiri Mahboobeh, Jahangirizadeh Kobra
Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
Int J Reprod Biomed. 2018 Jan;16(1):35-40.
Granulocyte colony-in stimulating factor () gene can be a potential candidate gene implicated recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age.
To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of gene and the risk of unexplained RPL among Iranian women.
In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. Tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects.
Statistically significant differences were detected between the distribution frequencies of both heterozygote CT, and carriage of T allele (TT+CT) genotypes of the rs1042658 between case and control groups. Allelic association was not observed with RPL.
Regarding the results of the present study, rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained RPL among Iranian women.
粒细胞集落刺激因子（）基因可能是复发性流产（RPL）的潜在候选基因，RPL是一种常见的妊娠并发症，在育龄妇女中的患病率为1-5%。
探讨基因3'非翻译区（3'UTR）中rs1042658多态性与伊朗妇女不明原因RPL风险之间的关联。
本病例对照研究共纳入122例不明原因RPL妇女和140例健康绝经后妇女作为对照组。采用四引物扩增阻滞突变系统-聚合酶链反应检测所有受试者的rs1042658基因型。
病例组和对照组之间rs1042658的杂合子CT以及T等位基因（TT+CT）基因型的分布频率存在统计学显著差异。未观察到等位基因与RPL的关联。
根据本研究结果，rs1042658基因多态性可被视为伊朗妇女不明原因RPL的一个可能危险因素。
