锌离子介导的叉肽自组装用于前列腺癌特异性药物递送。
Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery.
机构信息
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
出版信息
Chem Commun (Camb). 2018 May 7;54(37):4673-4676. doi: 10.1039/c8cc00604k. Epub 2018 Apr 20.
PMID:29675529
Abstract
A novel forky peptide was designed and synthesized. The peptide self-assembled into supramolecular hydrogels triggered by zinc ions (ZIs). The hydrogels were designed for a drug delivery system (DDS), loaded with docetaxel and applied for the therapy of prostate cancer. In this research, we have discussed the response mechanism and evaluated the anticancer effect of the DDS.
摘要
设计并合成了一种新型叉肽。该肽在锌离子（ZIs）的触发下自组装成超分子水凝胶。该水凝胶被设计用于药物传递系统（DDS），负载多西他赛，并应用于前列腺癌的治疗。在这项研究中，我们讨论了 DDS 的响应机制和评估了其抗癌效果。
Zotero 插件