State Key Laboratory of Cotton Biology, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, 475004, China.
Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, Kaifeng, 475004, China.
Sci China Life Sci. 2018 Apr;61(4):476-482. doi: 10.1007/s11427-017-9270-x. Epub 2018 Apr 1.
Surface plasmon resonance (SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS (Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.
基于金属纳米孔阵列的表面等离子体共振（SPR）纳米传感器已被广泛报道用于检测生物样本中的结合相互作用。对于 SPR 纳米传感器的发展，构建纳米级阵列的简单有效方法至关重要。在这项工作中，我们报告了一种通过在 IPS（中间聚合物压印模板）基质中热压印一步法来制造纳米孔阵列的方法。不需要额外的刻蚀工艺或支撑衬底。制备过程简单、省时，与卷对卷工艺兼容，具有大规模生产的潜力。此外，纳米孔阵列被集成到检测平台中作为 SPR 传感器，以研究不同类型的生物结合相互作用。结果表明，我们的一步法可以有效地制造大面积和均匀的纳米孔阵列，用于生化传感。
